IRON METABOLISM

DO YOU GUYS AWARE THAT OUR BLOOD NEED IRON?🩸🩸🩸

     Yes, iron is necessary for our blood to work properly. In actuality, myoglobin and haemoglobin, which are present in muscle cells and the blood, respectively, account for 70% of the body's total iron content. Lack of iron in the body can cause fatigue, anaemia, headaches, shortness of breath, and dizziness. It is highly advised to consume at least 18 mg per gramme. The intake requirements, however, differ based on a person's gender and stage of life. 

Food that rich in iron

          Our bodies obtain iron from the food we eat on a regular basis and transport it to the intestine and circulation in this way. Heme and nonheme types of iron can be categorised. Heme is an iron derived from animals, whereas nonheme is derived from plants. Both iron will enter the small intestine's lumen for absorption. They will connect to the plasma protein transferrin, which then allows red blood cells to receive the iron. The iron will then be utilised by the bone marrow to create fresh haemoglobin molecules. Any extra transferrin will be stored as two distinct protein-iron complexes in the liver and spleen. Hemosiderin or ferritin are the two options.

     Although the body benefits from iron, an excess of iron can be harmful. Diabetes, cardiac issues, and liver disease can all result from an excessive deposit of iron at storage sites like the liver and spleen. On the other side, a deficit in iron can result in iron-deficiency anaemia. This is so because the production of haemoglobin molecules in the bone marrow depends on iron, one of the essential components. Without iron, the body produces less haemoglobin and can oxygenate its tissues less effectively. In conclusion, getting enough iron is crucial, but you should only get what your body actually needs.

WHAT IS IRON METABOLISM?

HOW ITS WORKS?🤔

Iron Transport through the Enterocyte

    From this flow chart, we can get to know that the Iron is essential element and must be 

precisely regulated.Then, On the lumen side of small intestine iron is reduced from its ferric form known as (Fe3+) to ferrous form which is the (Fe2+).Moreover, the Ferrous iron will be transported in enterocytes by DMT1 known as the divalent metal transporter. In addition, this Iron  can be either stored within the enterocyte as ferritin or it can be transferred across the basolateral membrane to the plasma by transport protein called  FERROPORTIN1 and MTP1.It’s requires oxidation of Ferrous to Ferric by the hephaestin.

       

       The DMT1 called as Divalent Metal Transporter 1 will transports from lumen into the enterocytes.Then,the FERROPORTIN1 will transports from enterocytes to the circulation, in simple way it will transports iron from enterocytes to our blood vessels. In addition, for knowledge, in our muscle have myoglobins which requires the needs of iron.In conclusion, Hepicidin is the one who are the main role in iron metabolism.Thus, Hepicidin is a hormone and the key regulator of iron in our body.